New US-Russian Crew Docks at Space Station After Super-Fast Flight

A Soyuz rocket successfully delivered a trio of new residents to the International Space Station on the first-ever "express" flight to the orbiting laboratory.

The Russian rocket carrying NASA astronaut Chris Cassidy and Russian cosmonauts Alexander Misurkin and Pavel Vinogradov docked with the station on time at 10:28 p.m. EDT (0228 March 29 GMT) while both spacecraft flew high over the Pacific Ocean after a history-making six-hour flight.

"Expedition 35 now has a six member crew on board the space station,"NASA spokesman Josh Byerly said during the space agency's live comentary of the docking.

It has been a long day for the crew. Because of the launch's accelerated timescale, Misurkin, Vinogradov and Cassidy will not have had the chance to rest for 20 hours by the time they settle in for the first night in their new home.

The Soyuz TMA-08M's launch from the Baikonur Cosmodrome went smoothly with liftoff occurring at 4:43 p.m. EDT (2043 GMT). The three spaceflyers will stay on board the orbiting outpost until they return to Earth in September. [Launch Photos: Soyuz Rocket's 'Express' Flight to Station]

Before now, manned trips to the space station have taken at least two days, but with the docking of this ship just six hours after liftoff, marks the beginning of a new kind of mission that saves time and money, NASA officials have said.

"In my opinion, our mission is just next little step on the way, on the way to the moon, Mars, and I am very happy to do this step," Misurkin said in a preflight interview with NASA.

Russia's unmanned Progress cargo ships have made these express dockings before, but using the method for a crewed flight prevents the spaceflyers from spending extra time in a crowded capsule. Officials with the NASA also explained that these trips save money because a quicker flight means that Mission Control personnel will be on duty for a shorter amount of time.

The three newest residents of the International Space Station have a jam-packed stay ahead of them. A Russian Progress cargo spacecraft is scheduled to dock with the station at the end of May, and the crewmembers will perform spacewalks as well as help run the more than 100 science experiments while on board.

"We as human beings, we like to explore; there?s frontiers of knowledge, there?s frontiers of physical space that I think we all just feel compelled to go to and each one of those different types of environments, be it space or high mountains or the water, all bring different aspects to what we can learn, what can we can bring back to better life in either a small spectrum of our lives or in the broader sense of it," Cassidy said during an interview with NASA. "That?s how I think the space program is."

The three other residents of the station ? Canadian astronaut Chris Hadfield, Tom Marshburn of NASA and Russian cosmonaut Roman Romanenko ? will fly back to Earth in May. Vinogradov is set to take command upon their departure.

Cassidy was a crewmember on board the STS-127 space shuttle mission in 2009. Vinogradov flew to the Russian Mir space station in 1997 and the International Space Station in 2006. This is Misurkin's first time in orbit.

Follow Miriam Kramer @mirikramer and Google+. Follow us @Spacedotcom, Facebook?and Google+. Original article on SPACE.com.

Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/us-russian-crew-docks-space-station-super-fast-025755661.html

Latest Presidential Polls trump presidential debate debate marco scutaro

Maxsun Group Offers Great Discounts on Its Furniture In Celebration ...

?

PRLog (Press Release) - Mar. 28, 2013 - MASPETH, N.Y. -- Maxsun Group celebrates the recovery and regained success of the restaurant industry with a furniture sale. To encourage further growth in the industry, the New York based commercial furniture superstore is now offering some of its best-selling items on sale.

The Supply Company offers great discounts on a wide range of furniture items, from booths and tables, to patio furniture, bar stools and chairs for their customers who are about to open new restaurants or planning to refurbish existing restaurants.

The furniture supplier is offering its Ladder Back Bar Stool on sale at only $78.00 for restaurants looking to update their bar areas and give them a modern twist. This bar stool comes in standard with black walnut frame finish and a padded seat with vinyl upholstery or with plain wooden seat. Also, this bar stool is available in several frame finishes, such as light walnut, mahogeny, nature wood and black. The Maxsun Group's sale price on this item is indeed a bargain compared with the price of other suppliers of similar bar stool of around $90 to $95. ?

Another best-selling item on sale from Maxsun Group is the square oak wood table sets. A 24X24 inch square table with base included is on sale at price of $110.00. These tables will fit perfectly in any establishment. Whether it's upscale restaurants, small coffee shops or even the family dining room, these oak wood tables bring a warm and elegant characteristic that is only innate in all natural wood products.

Maxsun Group is also offering a variety of metal stack chairs for those looking for a simple and affordable seating option with price starting at only $23. You can assure that these chairs are durable, despite the low price, and are easily stored and stack. The Supply Company doesn't want customers wait too long to receive their orders; that's why the "Quickship Program" was recently launched by the company to make sure that orders will be delivered in only one to two days. ?

To view the complete selection of tables, outdoor furniture, bar stools and chairs that currently on sale, visit http://www.maxsungroup.com or call 718-669-7811 to talk with their customer service representative.

Source: http://www.prlog.org/12108124-maxsun-group-offers-great-discounts-on-its-furniture-in-celebration-of-restaurant-industrys-growth.html

jon jones chuck colson death meteor showers 2012 ufc 145 jones vs evans marian hossa philip humber

PFT: Browns won't release McCoy, may trade him

AP

When owners and teams treat football like a business, media and fans shrug.? When players do, it?s regarded as an affront to the integrity of the game.

It?s not fair, but that?s the way it is.? And Raiders quarterback Carson Palmer needs to brace himself for that reaction as he tries to force his way out of Oakland.

It?s obvious Palmer wants out.? Two years ago, he finagled his exit from Cincinnati by feigning retirement.? The strategy looked to be a failure until Raiders quarterback Jason Campbell broke his collarbone and former Raiders coach Hue Jackson lost his damn mind, giving up a first-round pick and a second-round pick for a quarterback who isn?t the guy he used to be.

Now, Palmer is turning up his nose at $10 million from the Raiders, which sets the stage for the Raiders eventually to cut him ? and for Palmer to play for someone else.

As Mike Silver of Yahoo! Sports explains it, Palmer wants to play for a contender, even if it means being a backup.? (Cough . . . Seahawks and Pete Carroll . . . cough.)? Of course, Palmer won?t get $10 million to be a backup, but his willingness to walk away from football in order to get out of Cincinnati proves that he?d be willing to walk away from $10 million in order to get a shot at winning.

Palmer?s posture also reflects a belief that, despite the hiring of G.M. Reggie McKenzie and coach Dennis Allen, Palmer doesn?t see the silver-and-black bus getting turned around in the immediate future.? Otherwise, he?d gladly take $10 million to stay put.

The problem is that the Raiders currently hold all the cards.? With no seven-figure trigger in Palmer?s deal, the $13 million doesn?t become fully guaranteed until Week One, which means the Raiders can cut him much later in the offseason, if they draft a quarterback early ? or if they eventually decide Terrelle Pryor can get the job done.? The only risk the Raiders are taking is that, if Palmer drops a dumbbell on his foot or pops an Achilles tendon in offseason conditioning drills or otherwise suffers a season-ending injury while on the clock, the Raiders will owe Palmer his full salary.

That could set the stage for a Steve McNair-style lockout.? Even without Palmer being barred from the building (which would violate the CBA), Palmer is making his second power play in two years.

When a team does it, we applaud.? Fair or not, Palmer should prepare for the jeers and the boos and the accusations of being a chronic quitter.

Source: http://profootballtalk.nbcsports.com/2013/03/28/banner-says-mccoy-wont-be-released-could-be-traded/related/

mississippi state chris carpenter chris carpenter dick cheney hcg drops reason rally mad hatter

The Uses of Electronics Recycling | Vernonvtpolice.com

Sorry, Readability was unable to parse this page for content.

Source: http://vernonvtpolice.com/shopping-and-product-reviews/the-uses-of-electronics-recycling/

screen actors guild royal rumble results sag awards 2012 kyra sedgwick honor killings mary tyler moore x games

Opposites attract: How cells and cell fragments move in electric fields

Mar. 28, 2013 ? Like tiny, crawling compass needles, whole living cells and cell fragments orient and move in response to electric fields -- but in opposite directions, scientists at the University of California, Davis, have found. Their results, published April 8 in the journal Current Biology, could ultimately lead to new ways to heal wounds and deliver stem cell therapies.

When cells crawl into wounded flesh to heal it, they follow an electric field. In healthy tissue there's a flux of charged particles between layers. Damage to tissue sets up a "short circuit," changing the flux direction and creating an electrical field that leads cells into the wound. But exactly how and why does this happen? That's unclear.

"We know that cells can respond to a weak electrical field, but we don't know how they sense it," said Min Zhao, professor of dermatology and ophthalmology and a researcher at UC Davis' stem cell center, the Institute for Regenerative Cures. "If we can understand the process better, we can make wound healing and tissue regeneration more effective."

The researchers worked with cells that form fish scales, called keratocytes. These fish cells are commonly used to study cell motion, and they also readily shed cell fragments, wrapped in a cell membrane but lacking a nucleus, major organelles, DNA or much else in the way of other structures.

In a surprise discovery, whole cells and cell fragments moved in opposite directions in the same electric field, said Alex Mogilner, professor of mathematics and of neurobiology, physiology and behavior at UC Davis and co-senior author of the paper.

It's the first time that such basic cell fragments have been shown to orient and move in an electric field, Mogilner said. That allowed the researchers to discover that the cells and cell fragments are oriented by a "tug of war" between two competing processes.

Think of a cell as a blob of fluid and protein gel wrapped in a membrane. Cells crawl along surfaces by sliding and ratcheting protein fibers inside the cell past each other, advancing the leading edge of the cell while withdrawing the trailing edge.

Assistant project scientist Yaohui Sun found that when whole cells were exposed to an electric field, actin protein fibers collected and grew on the side of the cell facing the negative electrode (cathode), while a mix of contracting actin and myosin fibers formed toward the positive electrode (anode). Both actin alone, and actin with myosin, can create motors that drive the cell forward.

The polarizing effect set up a tug-of-war between the two mechanisms. In whole cells, the actin mechanism won, and the cell crawled toward the cathode. But in cell fragments, the actin/myosin motor came out on top, got the rear of the cell oriented toward the cathode, and the cell fragment crawled in the opposite direction.

The results show that there are at least two distinct pathways through which cells respond to electric fields, Mogilner said. At least one of the pathways -- leading to organized actin/myosin fibers -- can work without a cell nucleus or any of the other organelles found in cells, beyond the cell membrane and proteins that make up the cytoskeleton.

Upstream of those two pathways is some kind of sensor that detects the electric field. In a separate paper to be published in the same journal issue, Mogilner and Stanford University researchers Greg Allen and Julie Theriot narrow down the possible mechanisms. The most likely explanation, they conclude, is that the electric field causes certain electrically charged proteins in the cell membrane to concentrate at the membrane edge, triggering a response.

The team also included Hao Do, Jing Gao and Ren Zhao, all at the Institute for Regenerative Cures and the UC Davis departments of Ophthalmology and Dermatology. Sun is co-advised by Mogilner and Zhao; Gao is now working at Yunnan Normal University, Kunming, China, and Ren Zhao is at the Third Military Medical University, Chongqing, China.

The work was funded by the National Institutes of Health, the California Institute for Regenerative Medicine and the National Science Foundation.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by University of California - Davis.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Yaohui Sun, Hao Do, Jing Gao, Ren Zhao, Min Zhao, Alex Mogilner. Keratocyte Fragments and Cells Utilize Competing Pathways to Move in Opposite Directions in an Electric Field. Current Biology, 2013; DOI: 10.1016/j.cub.2013.02.026

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/electricity/~3/lasFFKFuUus/130328125100.htm

angelina jolie leg daytona artie lange nascar daytona 2012 kasey kahne angelina jolie right leg saving face

New sensor cable enables remote monitoring of miles of perimeter fencing

Public release date: 27-Mar-2013
[ | E-mail | Share ]

Contact: Uwe Hartmann
u.hartmann@mx.uni-saarland.de
Saarland University

Hannover Messe / Hanover Fair

Airports, nuclear power stations, industrial and research sites, or even your own garden there are many places that need to be protected against unauthorized access, and often protection is required 24 hours a day, seven days a week. Up until now, the sheer length of the perimeter to be protected and the high costs involved made this sort of protection impossible at many sites. Working in collaboration with a number of companies, research scientists at Saarland University have developed a new type of surveillance technology that enables extended perimeters to be monitored and protected at low cost. The new technology is based on magnetometers (magnetic field sensors) that can be incorporated within smart cables of essentially any length. These cables can themselves be installed into fencing or roadways. The research team is presenting its innovative technology at the major international technology fair Hannover Messe from April 8th to April 12th (Stand C 40, Hall 2 ? Saarland Research and Innovation Stand).

If an intruder wants to gain access to a secure industrial site, he first has to overcome some sort of physical barrier, typically a fence. If he climbs the fence or cuts the links he will, unavoidably, cause a vibrational disturbance, which will disclose his position to the novel detection system that has been developed by Uwe Hartmann, Professor for Experimental Physics at Saarland University, and research assistant Haibin Gao. No matter how small the disturbance, each movement of the fence influences the Earth's magnetic field and these changes are detected by the system's tiny, highly sensitive magnetometers.

The magnetometer probes are arranged within the cable like beads on a necklace and the cable is incorporated either permanently or temporarily into the fence. The cable can also be buried in the ground, in which case it responds to any changes in the magnetic field above it. The tiny probes form part of a bus communication network and immediately report any physical disturbance or change including information on where the vibration occurred and whether or not the change in the magnetic field was caused by a human intruder.

The researchers need to be able to exclude false alarms triggered by wind, animals or some other harmless cause. This they do by using complex algorithms to analyse the signals generated by the individual sensors. These algorithms are currently being developed and refined in order to unambiguously distinguish natural disturbances from the disturbances caused by a human intruder.

"The smart sensor cable does not require any major conversion work to be carried out before it can be used, and makes barbed wire and camera surveillance superfluous," says Professor Hartmann. "The system does not record any personal data. The sensors report only the information that is needed for protecting property or for monitoring, say, rail traffic: Has a disturbance occurred? If it has, where did it occur and was it caused by human interference? No other information about the person is recorded," explains Hartmann.

The prototype of the "Vibromag Cable" that Uwe Hartmann and his team developed in conjunction with St. Ingbert-based company Votronic Technology GmbH is now to be developed to production standard. This is the objective of a new project starting in August 2013 in which the Saarbrcken physicists will be teaming up with three partner companies, each of which became aware of the new technology at the 2012 Hannover Messe. The three companies are: Sensitec GmbH, based in Mainz and Lahnau (http://www.sensitec.com), Listec GmbH from Isen (http://www.listec-gmbh.com), and GBA-Panek GmbH whose headquarters are in Kahla, south of Jena (http://www.gba-panek.de).

The Saarland Research and Innovation stand at Hannover Messe is organized by Saarland University's Contact Centre for Technology Transfer (KWT).

###

For further information, please contact:

Prof. Dr. Uwe Hartmann, Nanostructure Research and Nanotechnology Group, Department of Experimental Physics, Saarland University, Germany Tel.: +49 (0)681 302-3799 or -3798; E-mail: u.hartmann@mx.uni-saarland.de

Press photographs are available at http://www.uni-saarland.de/pressefotos and can be used at no charge. Please read and comply with the conditions of use.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 27-Mar-2013
[ | E-mail | Share ]

Contact: Uwe Hartmann
u.hartmann@mx.uni-saarland.de
Saarland University

Hannover Messe / Hanover Fair

Airports, nuclear power stations, industrial and research sites, or even your own garden there are many places that need to be protected against unauthorized access, and often protection is required 24 hours a day, seven days a week. Up until now, the sheer length of the perimeter to be protected and the high costs involved made this sort of protection impossible at many sites. Working in collaboration with a number of companies, research scientists at Saarland University have developed a new type of surveillance technology that enables extended perimeters to be monitored and protected at low cost. The new technology is based on magnetometers (magnetic field sensors) that can be incorporated within smart cables of essentially any length. These cables can themselves be installed into fencing or roadways. The research team is presenting its innovative technology at the major international technology fair Hannover Messe from April 8th to April 12th (Stand C 40, Hall 2 ? Saarland Research and Innovation Stand).

If an intruder wants to gain access to a secure industrial site, he first has to overcome some sort of physical barrier, typically a fence. If he climbs the fence or cuts the links he will, unavoidably, cause a vibrational disturbance, which will disclose his position to the novel detection system that has been developed by Uwe Hartmann, Professor for Experimental Physics at Saarland University, and research assistant Haibin Gao. No matter how small the disturbance, each movement of the fence influences the Earth's magnetic field and these changes are detected by the system's tiny, highly sensitive magnetometers.

The magnetometer probes are arranged within the cable like beads on a necklace and the cable is incorporated either permanently or temporarily into the fence. The cable can also be buried in the ground, in which case it responds to any changes in the magnetic field above it. The tiny probes form part of a bus communication network and immediately report any physical disturbance or change including information on where the vibration occurred and whether or not the change in the magnetic field was caused by a human intruder.

The researchers need to be able to exclude false alarms triggered by wind, animals or some other harmless cause. This they do by using complex algorithms to analyse the signals generated by the individual sensors. These algorithms are currently being developed and refined in order to unambiguously distinguish natural disturbances from the disturbances caused by a human intruder.

"The smart sensor cable does not require any major conversion work to be carried out before it can be used, and makes barbed wire and camera surveillance superfluous," says Professor Hartmann. "The system does not record any personal data. The sensors report only the information that is needed for protecting property or for monitoring, say, rail traffic: Has a disturbance occurred? If it has, where did it occur and was it caused by human interference? No other information about the person is recorded," explains Hartmann.

The prototype of the "Vibromag Cable" that Uwe Hartmann and his team developed in conjunction with St. Ingbert-based company Votronic Technology GmbH is now to be developed to production standard. This is the objective of a new project starting in August 2013 in which the Saarbrcken physicists will be teaming up with three partner companies, each of which became aware of the new technology at the 2012 Hannover Messe. The three companies are: Sensitec GmbH, based in Mainz and Lahnau (http://www.sensitec.com), Listec GmbH from Isen (http://www.listec-gmbh.com), and GBA-Panek GmbH whose headquarters are in Kahla, south of Jena (http://www.gba-panek.de).

The Saarland Research and Innovation stand at Hannover Messe is organized by Saarland University's Contact Centre for Technology Transfer (KWT).

###

For further information, please contact:

Prof. Dr. Uwe Hartmann, Nanostructure Research and Nanotechnology Group, Department of Experimental Physics, Saarland University, Germany Tel.: +49 (0)681 302-3799 or -3798; E-mail: u.hartmann@mx.uni-saarland.de

Press photographs are available at http://www.uni-saarland.de/pressefotos and can be used at no charge. Please read and comply with the conditions of use.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-03/su-nsc032713.php

odd lamar d antoni fashion star andrew bird lizzie borden lizzie borden

Details of gene pathways suggest fine-tuning drugs for child brain tumors

Mar. 26, 2013 ? Pediatric researchers, investigating the biology of brain tumors in children, are finding that crucial differences in how the same gene is mutated may call for different treatments. A new study offers glimpses into how scientists will be using the ongoing flood of gene-sequencing data to customize treatments based on very specific mutations in a child's tumor.

"By better understanding the basic biology of these tumors, such as how particular mutations in the same gene may respond differently to targeted drugs, we are moving closer to personalized medicine for children with cancer," said the study's first author, Angela J. Sievert, M.D., M.P.H., an oncologist in the Cancer Center at The Children's Hospital of Philadelphia.

Sievert, working with co-first author Shih-Shan Lang, M.D., in the translational laboratory of neurosurgeon Phillip Storm, M.D., and Adam Resnick, Ph.D., published a study ahead of print today in the Proceedings of the National Academy of Sciences.

The study, performed in cell cultures and animals, focused on a type of astrocytoma, the most common type of brain tumor in children. When surgeons can fully remove an astrocytoma (also called a low-grade glioma), a child can be cured. However, many astrocytomas are too widespread or in too delicate a site to be safely removed. Others may recur. So pediatric oncologists have been seeking better options -- ideally, a drug that can selectively and definitively kill the tumor with low toxicity to healthy tissue.

The current study focuses on mutations in the BRAF gene, one of the most commonly mutated genes in human cancers. Because the same gene is also mutated in certain adult cancers, such as melanoma, the pediatric researchers were able to make use of recently developed drugs, BRAF inhibitors, which were already being tested with some success against melanoma in adults.

The current study provides another example of the complexity of cancer: in the same gene, different mutations behave differently. Sievert and her colleagues at Children's Hospital were among several research groups who reported almost simultaneously in 2008 and 2009 that mutations in the BRAF gene were highly prevalent in astrocytomas in children. "These were landmark discoveries, because they suggested that if we could block the action of that mutation, we could develop a new, more effective treatment for these tumors," said Sievert.

However, follow-up studies in animal models were initially disappointing. BRAF inhibitors that were effective in BRAF-driven adult melanomas made brain tumors worse -- via an effect called paradoxical activation.

Further investigation revealed how tumor behavior depended on which type of BRAF mutation was involved. The first-generation drug that was effective in adult melanoma acted against point mutations in BRAF called V600E alterations. However, in most astrocytomas the mutation in the BRAF gene was different; it produced a fusion gene, designated KIAA1549-BRAF. When used against the fusion gene, the first-generation drug activated a cancer-driving biological pathway, the MAPK signaling cascade, and accelerated tumor growth.

By examining the molecular mechanisms behind drug resistance and working with the pharmaceutical industry, the current study's investigators identified a new, experimental second-generation BRAF inhibitor that disrupted the cancer-promoting signals from the fusion gene, and did not cause the paradoxical activation in the cell cultures and animal models.

This preclinical work result lays a foundation for multicenter clinical trials to test the mutation-specific targeting of tumors by this class of drugs in children with astrocytomas, said Sievert. As this effort progresses, it will benefit from CHOP's commitment to resources and collaborations that support data-intense research efforts.

The direction of brain tumor research over the past several years reflects some of those data-driven advances, says Adam C. Resnick, Ph.D., the senior author of the current paper and principal investigator of the astrocytoma research team in the Division of Neurosurgery at Children's Hospital. "For years, astrocytomas have been lumped together based on similar appearance to pathologists studying their structure, cell shape and other factors," said Resnick. "But our current discoveries show that the genetic and molecular structure of tumors provides more specific information in guiding oncologists toward customized treatments."

Earlier this year, Children's Hospital announced its collaboration with the gene-sequencing organization BGI-Shenzhen in performing next-generation sequencing of pediatric brain tumors at the Joint Genome Center, BGI@CHOP. The center's sophisticated, high-throughput sequencing technology will greatly speed the discovery of specific gene alterations involved in childhood brain cancers.

This genomic discovery program dovetails with the work of the Childhood Brain Tumor Tissue Consortium, a multi-institutional collaboration recently launched by CHOP, with support from the Children's Brain Tissue Foundation. Because even large research centers may not hold enough tumor tissue specimens to power certain research, the consortium pools samples from a group of institutions, providing an important scientific resource for cooperative studies.

"The better we understand the mutational landscape of tumors, the closer we'll be to defining therapies tailored to a patient's specific subtype of cancer," added Resnick.

Funding from the National Institutes of Health (grants CA076931 and 5T32043126-09), the Matthew Larson Pediatric Brain Tumor Foundation, Alex's Lemonade Stand Foundation, the Rally Foundation for Childhood Cancer Research, the Bear Necessities Pediatric Cancer Foundation and A Kid's Brain Tumor Cure/PLGA Foundation supported this study. Plexxikon, Inc., provided the BRAF inhibitors used in the study. Sievert, Resnick and Storm are all on the faculty of the Perelman School of Medicine at the University of Pennsylvania in addition to their positions at Children's Hospital.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by Children's Hospital of Philadelphia.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Angela J. Sievert, Shih-Shan Lang et al. Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. Proceedings of the National Academy of Sciences, March 26, 2013 DOI: 10.1073/pnas.1219232110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/AF1-VuJHPHs/130326133218.htm

lint buenos aires train crash argentina train crash nancy pelosi nancy pelosi gop debate republican debate

Where to Drink During the Craft Brewers Conference This Week ...

The annual?Craft Brewers Conference arrives in D.C. this week. More than 6,000 beer professionals from around the world are expected to attend, and many are bringing their beer with them. Gird your liver!

Washington's plethora of craft beer-minded bars and restaurants have put together a whopper of a week to celebrate the first time the Brewers Association holds the event in the nation's capital.?We've sorted through the public events around town and put together some of our top picks for each day:

MONDAY, March 25

CBC Beer & Food Experience at ChurchKey (4 p.m. to close)

Tickets for the five-course pairing dinner at Birch & Barley are long gone, but drafts and casks from the five participating breweries will flow in the upstairs bar at ChurchKey. The lineup includes six Bluejacket collaborations and a slew of brews from DC Brau, Flying Dog, Cigar City, Surly, Firestone Walker, and Maui.

Belgian in the U.S.A at Brasserie Beck (4 p.m. to close)

The Belgian bistro will feature Belgian-style brews from Brewery Ommegang of upstate New York, Maine?s Allagash Brewing, and Boulevard Brewing from Missouri. Representatives from each will be present to discuss their brews, and drafts will be $6 until 7 p.m. The beer to go for: Allagash FV 13, a sour brown ale aged in large wooden casks for four years.

East Coast vs. West Coast Punk Rock Brew Tour at Meridian Pint (7 p.m. to 12 a.m.)

Head down to the basement for an evening of raging punk and hardcore tracks and a chance to vote for the best India pale ales from two rival teams. The East Coast roster includes Smuttynose, Victory, and Sixpoint. Challengers from the west are Lagunitas, Ballast Point, Oskar Blues, and Sierra Nevada.

TUESDAY, March 26

The Great American Saison Draft Feature at ChurchKey (4 p.m. to close)

Sample from 40 of the best farmhouse ales and saisons brewed in the U.S. The all-star brewery line-up includes Jester King, Saint Somewhere, Hill Farmstead, Tired Hands, Crooked Stave, Cambridge, Prairie, Stillwater, Oxbow, Perennial, and Bluejacket. As an added bonus, the bar will feature 20 beers from Michigan's innovative Short's Brewing Company. It's a two-fer!

Hop Kitchen Hop Symposium with DCBeer.com at Smith Commons (7 p.m. to 10 p.m.)

Smith Commons kicks off a week of Masters of the Craft Beer Universe events with a night devoted to America's favorite beer ingredient. Head to H Street NE for an evening of hoppy beers, food pairings, and lively discussion with featured guests like Brian Strumke of Stillwater Artisanal Ales, Matty Gilliland and John Gartner of New Belgium Brewing, J.T. Smith of the Brewers Association of Maryland, and Bill Jusino and Mike Tonsmeire of DC Homebrewers.

Great Lakes Beer Extravaganza at Sixth Engine (5 p.m.)

The ever popular Great Lakes Brewing Company from Cleveland will pour some rarities, like Tripel Dog Dare and Alberta Clipper Winter Porter, and tap a special keg of Barrel-Aged Blackout Stout at 9 p.m.

WEDNESDAY, March 27

Goose Island Tap Takeover featuring Bourbon County at Smoke & Barrel (5 p.m.)

Those lucky enough to get tickets will be the first to sample from three rare Bourbon County kegs starting at 3:30 p.m. and enjoy an intimate chat with Goose Island head cellarman Brian Taylor. Doors open to the public at 5 p.m., and the beer list includes a dozen treats from the Illinois brewery?s broad portfolio.

Night of Extraordinary Ales at Scion and Crios (5 p.m.)

The Dupont Circle craft beer-focused restaurants will together pour 40 beers from nine breweries that are nearly impossible to find in D.C. The list includes drafts and bottles from Falling Sky, Funkwerks, Two Brothers, Oakshire, Haymarket, Gigantic, Foothills, Fullsteam, and Odell.

Flying Dog ?Cask Off? and Le Trou du Diable Brewer Meet & Greet at Pizzeria Paradiso Georgetown (5 p.m.)

Flying Dog and Pizzeria Paradiso each infused a cask of Doggie Style Pale Ale with special ingredients. It?s up to you which turned out best in this cask-conditioning competition. Bonus: The brewers from Quebec?s Le Trou du Diable brewery will be on hand with six of their sensational ales. Double bonus: All beers are half price from 5 to 7 p.m.

Baltimore Beer Night at Boundary Road (5:30 p.m.)

Brewers from four Baltimore breweries will be on hand to showcase their talents. The list includes drafts, bottles, and cans from The Brewer?s Art, Stillwater, Oliver Ales, and Union Craft Brewing. Highlights include Brewer?s Art Tiny Tim, a buckwheat honey ale with hibiscus and rosemary, and Olivers Winter?s Wolves, a dark ale brewed with honey and Scottish Heather and aged on American oak.

THURSDAY, March 28

Anchor Tap Takeover and Brewer Meet & Greet at RFD (6 p.m.)

Meet brewmaster Mark Carpenter and other members of San Francisco?s Anchor Brewing crew while sampling from five of their standards as well as several rarities and new releases. The list includes Small Beer, California Lager, and OBA, a blend of Anchor beers aged in house whiskey barrels from Anchor Distilling Old Potrero Rye Whiskey.

3 Floyds, Surly and Elysian Tap Takeovers at Pizzeria Paradiso Georgetown and Dupont Circle (5 p.m. to close)

Three Floyds of Indiana will share taps with Minnesota?s Surly Brewing Company at Paradiso?s Dupont location and Washington?s Elysian Brewing at the Georgetown location. Treats from 3 Floyds are as of yet TBD, but highlights from Surly include Furious, Pentagram, Coffee Bender, and Cynic. Elysian will have The Dread, Yuzu Belgian Golden and Avatar Jasmine IPA among others.

A Can-Do Spirit and Rocky Mountain Hops at The Black Squirrel (5 to 7 p.m.)

The downstairs tap room will feature canned beers from Golden Road, Oskar Blues, Maui, and Ska Brewing. Have a first look at Oskar Blues? new 19.2 ounce tall cans of Dale?s Pale Ale and Mama?s Little Yella Pils. Should go down great with half-price burgers. Also enjoy rare hoppy brews from six Colorado breweries: Avery, Odell, New Belgium, Breckenridge, Funkwerks, and Oskar Blues.

FRIDAY, March 29

Drink Local at Meridian Pint (1 p.m. to close)

The Columbia Heights bar?s taps will be taken over by 20 local beers, all only $5 a pour all day long. Some of the featured D.C., Virginia, and Maryland breweries include DC Brau, 3 Stars, Chocolate City, Franklin?s, Lost Rhino, Mad Fox, Port City, Oliver Breweries, Stillwater, Union Craft Brewing, DuClaw, The Brewery?s Art, Devils Backbone, Blue Mountain, and Flying Dog. The event is sponsored in part by BeerAdvocate.

Samuel Adams Small Batch Takeover at Bourbon Glover Park (6 to 9 p.m.)

Boston Beer Company makes more than Sam Adams Boston Lager. Find out more about their small batch beers such as a recently recreated pale ale from the legendary ?original? American craft brewery New Albion. They will also be pouring samples of Utopias, a 27 percent alcohol specialty blend of barrel aged beer.

Oskar Blues Beer & Food Pairings at Bier Baron Tavern (8 to 10 p.m.)

The Colorado brewery and chain of restaurants is known for pairing beer and food. Try the beers and inspired recipes together.

Image courtesy of the Brewers Association

Follow The Lagerheads on Twitter | on Facebook

Source: http://www.washingtoncitypaper.com/blogs/youngandhungry/2013/03/25/where-to-drink-during-the-craft-brewers-conference-this-week/

storm chasers david blaine gotye divine mercy cabin in the woods the legend of korra three stooges

Jessie Ware's 'Wicked' Year: A$AP Rocky And MTV's Artist To Watch Honors

The much-buzzed singer is one of MTV's picks for 2013, and she's already winning over audiences in the U.S.
By James Montgomery

Jessie Ware
Photo: isifa/Getty

Source: http://www.mtv.com/news/articles/1704312/jessie-ware-mtv-artist-to-watch.jhtml

Honey Boo Boo pirate bay Psalms 91 once upon a time once upon a time RG3 Monsters University

Toobin: Court divided (CNN)

Share With Friends: | | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/294741016?client_source=feed&format=rss

sean young juan pablo montoya free pancakes at ihop martina navratilova high school shooting ohio school shooting sean young arrested

Slickdeals' best in tech for March 25th: Nest Learning Thermostat and more

Looking to save some coin on your tech purchases? Of course you are! In this round-up, we'll run down a list of the freshest frugal buys, hand-picked with the help of the folks at Slickdeals. You'll want to act fast, though, as many of these offerings won't stick around long.

Mondays serve as a cruel reminder that the weekend is over, but a few gadget deals could ease the transition a bit. Nest's first-gen Learning Thermostat hits the list today alongside a 42-inch LG 3D HDTV and much more. A quick jaunt past the break will reveal all of the selections and the requisite purchase info.

Filed under: Displays, Misc, Home Entertainment, Household

Comments

Source: Slickdeals

Source: http://www.engadget.com/2013/03/25/slickdeals-best-in-tech-for-march-25th/

johan santana viktor bout ncaa hockey role models ferdinand porsche gregg williams theraflu

Wichita State Win: Gonzaga Upset By Shockers In NCAA Tournament

Wichita State vs. Gonzaga

Carl Hall #22 of the Wichita State Shockers dunks the ball in the first half while taking on the Gonzaga Bulldogs during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Harry How/Getty Images)

Wichita State vs. Gonzaga

Carl Hall #22 of the Wichita State Shockers steals the ball from Gary Bell, Jr. #5 of the Gonzaga Bulldogs alongside Demetric Williams #5 of the Shockers in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Harry How/Getty Images)

Wichita State vs. Gonzaga

Demetric Williams #5 of the Wichita State Shockers and Kevin Pangos #4 of the Gonzaga Bulldogs go after a loose ball in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Streeter Lecka/Getty Images)

Wichita State vs. Gonzaga

Kevin Pangos #4 of the Gonzaga Bulldogs reacts in the first half while taking on the Wichita State Shockers during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Harry How/Getty Images)

Wichita State vs. Gonzaga

Kelly Olynyk #13 of the Gonzaga Bulldogs drives to the basket against Ehimen Orukpe #21 and Carl Hall #22 of the Wichita State Shockers in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Streeter Lecka/Getty Images)

Wichita State vs. Gonzaga

Ron Baker #31 of the Wichita State Shockers and Elias Harris #20 of the Gonzaga Bulldogs go after a loose ball in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Streeter Lecka/Getty Images)

Wichita State vs. Gonzaga

Carl Hall #22 of the Wichita State Shockers and Kelly Olynyk #13 of the Gonzaga Bulldogs go after a loose ball in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Streeter Lecka/Getty Images)

Wichita State vs. Gonzaga

Cleanthony Early #11 of the Wichita State Shockers blocks Sam Dower #35 of the Gonzaga Bulldogs in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Harry How/Getty Images)

Wichita State vs. Gonzaga

Cleanthony Early #11 of the Wichita State Shockers reacts after making a three-pointer in the first half against the Gonzaga Bulldogs during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Streeter Lecka/Getty Images)

Wichita State vs. Gonzaga

Carl Hall #22 of the Wichita State Shockers dunks the ball in the first half while taking on the Gonzaga Bulldogs during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Harry How/Getty Images)

Wichita State vs. Gonzaga

Ron Baker #31 of the Wichita State Shockers and Elias Harris #20 of the Gonzaga Bulldogs go after a loose ball in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Streeter Lecka/Getty Images)

Wichita State vs. Gonzaga

Carl Hall #22 and Cleanthony Early #11 of the Wichita State Shockers react after Early makes a three-pointer in the first half against the Gonzaga Bulldogs during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Streeter Lecka/Getty Images)

Wichita State vs. Gonzaga

Mike Hart #30 of the Gonzaga Bulldogs and Carl Hall #22 of the Wichita State Shockers go after a loose ball in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at EnergySolutions Arena on March 23, 2013 in Salt Lake City, Utah. (Photo by Streeter Lecka/Getty Images)

Butler vs. Marquette

Trent Lockett #22 of the Marquette Golden Eagles dives for the ball against Kellen Dunham #24 of the Butler Bulldogs in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Butler vs. Marquette

Trent Lockett #22 of the Marquette Golden Eagles grabs a loose ball against Roosevelt Jones #21 of the Butler Bulldogs in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Butler vs. Marquette

Head coach Buzz Williams of the Marquette Golden Eagles looks on from the sideline in the first half against the Butler Bulldogs during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Butler vs. Marquette

Andrew Smith #44 of the Butler Bulldogs drives to the basket and draws a foul against Davante Gardner #54 of the Marquette Golden Eagles in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Butler vs. Marquette

Junior Cadougan #5 of the Marquette Golden Eagles shoots against Kellen Dunham #24 of the Butler Bulldogs in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Andy Lyons/Getty Images)

Butler vs. Marquette

Andrew Smith #44 of the Butler Bulldogs reacts after a play against the Marquette Golden Eagles in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Andy Lyons/Getty Images)

Butler vs. Marquette

Derrick Wilson #12 and Trent Lockett #22 of the Marquette Golden Eagles celebrate after a defensive play in the first half against the Butler Bulldogs during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Andy Lyons/Getty Images)

Butler vs. Marquette

Rotnei Clarke #15 of the Butler Bulldogs reacts after making a basket against the Marquette Golden Eagles in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Butler vs. Marquette

Jamil Wilson #0 of the Marquette Golden Eagles reacts after having a foul called on him in the first half against the Butler Bulldogs during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Butler vs. Marquette

Head coach Brad Stevens of the Butler Bulldogs talks to his players after a double flagrant foul in the first half against the Marquette Golden Eagles during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Butler vs. Marquette

Jamil Wilson #0 of the Marquette Golden Eagles handles the ball against Roosevelt Jones #21 of the Butler Bulldogs in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Oregon vs. Saint Louis

Cody Ellis #24 is called for a foul as he and Jordair Jett #5 of the Saint Louis Billikens defend against Johnathan Loyd #10 of the Oregon Ducks in the second half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

Cody Ellis #24 of the Saint Louis Billikens drives past Carlos Emory #33 of the Oregon Ducks in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

Cody Ellis #24 of the Saint Louis Billikens and Arsalan Kazemi #14 of the Oregon Ducks vie for posession in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

The Oregon Ducks bench reacts in the first half against the Saint Louis Billikens during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Thearon W. Henderson/Getty Images)

Oregon vs. Saint Louis

Arsalan Kazemi #14 passes the ball to Damyean Dotson #21 of the Oregon Ducks on a fast break in the first half against the Saint Louis Billikens during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

Rob Loe #51 of the Saint Louis Billikens goes up against the Oregon Ducks in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Thearon Henderson/Getty Images)

Oregon vs. Saint Louis

Arsalan Kazemi #14 of the Oregon Ducks drives against Cody Ellis #24 of the Saint Louis Billikens in the fist half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

Head coach Jim Crews talks to Kwamain Mitchell #3 and Grandy Glaze #1 of the Saint Louis Billikens in the first half against the Oregon Ducks during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

Kwamain Mitchell #3 of the Saint Louis Billikens drives against Arsalan Kazemi #14 of the Oregon Ducks in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

E.J. Singler #25 of the Oregon Ducks falls on Dwayne Evans #21 of the Saint Louis Billikens as Jordair Jett #5 of the Saint Louis Billikens recovers the loose ball in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

Grandy Glaze #1 of the Saint Louis Billikens drives against Tony Woods #55 of the Oregon Ducks in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Thearon Henderson/Getty Images)

Oregon vs. Saint Louis

Arsalan Kazemi #14 of the Oregon Ducks rebounds over Grandy Glaze #1 of the Saint Louis Billikens in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

Tony Woods #55 of the Oregon Ducks goes up for a shot over Rob Loe #51 of the Saint Louis Billikens in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

Head coach Dana Altman (L) and assistant coach Tony Stubblefield of the Oregon Ducks react in the first half against the Saint Louis Billikens during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

Damyean Dotson #21 of the Oregon Ducks goes up against the Saint Louis Billikens in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Oregon vs. Saint Louis

Mike McCall Jr. #11 of the Saint Louis Billikens guards Johnathan Loyd #10 of the Oregon Ducks in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Thearon Henderson/Getty Images)

Oregon vs. Saint Louis

Arsalan Kazemi #14 of the Oregon Ducks rebounds over Grandy Glaze #1 of the Saint Louis Billikens in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at HP Pavilion on March 23, 2013 in San Jose, California. (Photo by Ezra Shaw/Getty Images)

Colorado State vs. Louisville

Kevin Ware #5 of the Louisville Cardinals defends Wes Eikmeier #10 of the Colorado State Rams in the second half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Andy Lyons/Getty Images)

Colorado State vs. Louisville

Colton Iverson #45 of the Colorado State Rams looks on in the first half agaisnt the Louisville Cardinals during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Colorado State vs. Louisville

Peyton Siva #3 of the Louisville Cardinals falls trying to dribble around Colton Iverson #45 of the Colorado State Rams in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Colorado State vs. Louisville

Montrezl Harrell #24 of the Louisville Cardinals takes a charge as Colton Iverson #45 of the Colorado State Rams goes up for a dunk in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Colorado State vs. Louisville

Colton Iverson #45 of the Colorado State Rams handles the ball against Stephan Van Treese #44 of the Louisville Cardinals in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Colorado State vs. Louisville

Montrezl Harrell #24 of the Louisville Cardinals reacts after a play against the Colorado State Rams in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Colorado State vs. Louisville

Dorian Green #22 of the Colorado State Rams celebrates after making a three point basket against the Louisville Cardinals in the first half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Colorado State vs. Louisville

Colton Iverson #45 of the Colorado State Rams looks up after being poked in the eye in the first half against the Louisville Cardinals during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Colorado State vs. Louisville

Peyton Siva #3 of the Louisville Cardinals steals the ball from Greg Smith #44 of the Colorado State Rams in the second half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Colorado State vs. Louisville

Colton Iverson #45 of the Colorado State Rams handles the ball and is fouled by Gorgui Dieng #10 of the Louisville Cardinals in the second half during the third round of the 2013 NCAA Men's Basketball Tournament at Rupp Arena on March 23, 2013 in Lexington, Kentucky. (Photo by Kevin C. Cox/Getty Images)

Source: http://www.huffingtonpost.com/2013/03/23/wichita-state-win-gonzaga-ncaa_n_2941956.html

Marvin Hamlisch Megan Rossee grenada grenada Sikh Sanya Richards Ross decathlon

Israel fires missile at Syrian military post

March 24, 2013

JERUSALEM?(JTA) -- The Israel Defense Forces fired a missile at a Syrian military post in response to fire on Israeli troops in the Golan Heights.

The missile fired Sunday destroyed the military post and reportedly injured two Syrian soldiers.

The Israeli attack came after gunfire from Syria struck an IDF jeep on Saturday night, damaging the vehicle. Israeli soldiers also came under fire on Sunday morning. No Israeli soldiers were injured in the attacks.

"We take the firing of bullets at IDF forces in Israeli territory very seriously. In response the IDF returned fire in line with the government policy: Any violation of Israeli sovereignty and fire from the Syrian side will be answered with the silencing of the source of fire. The Syrian regime is responsible for every breach of sovereignty. We will not allow the Syrian army or any other groups to violate Israel's sovereignty in any way," Israeli Defense Minister Moshe Yaalon said in a statement.

It is unclear whether the bullets fired into Israeli territory had gone astray as part of Syria's civil war, or if they were fired intentionally at Israeli troops.

It is not the first time that gunfire from Syria has struck Israeli targets in recent months. In some cases, Israel has retaliated.

Israel has also cared for injured Syrian rebels in at least two instances in recent weeks.

Israeli Prime Minister Benjamin Netanyahu said Saturday night in a Facebook post that some of his motivation in apologizing to Turkey on March 22 for the Mavi Marmara incident was because of the threat from Syria as its civil war continues to escalate.??

"It?s important that Turkey and Israel, which both share a border with Syria, are able to communicate with each other and this is also relevant to other regional challenges. In addition, the visit of US President Barack Obama and Secretary of State Kerry created an opportunity to end the crisis," Netanyahu wrote. "Syria is crumbling, and its massive stockpiles of advanced weapons are starting to fall into the hands of various elements. What we fear most is that terrorist groups will get their hands on chemical weapons."

ADVERTISEMENT: Visit OneHappyCamper.org to find a Jewish camp and see if your child qualifies for a $1,000 grant.

Click to write a letter to the editor.

This article was made possible by the support of readers like you. Donate to JTA now.

Source: http://www.jta.org/news/article/2013/03/24/3122901/israel-fires-missile-at-syrian-military-post

lawrence o donnell magic johnson jetblue pilot solicitor general neighborhood watch dodgers sale tami roman

Computer simulations yield clues to how cells interact with surroundings

Mar. 22, 2013 ? Your cells are social butterflies. They constantly interact with their surroundings, taking in cues on when to divide and where to anchor themselves, among other critical tasks.

This networking is driven in part by proteins called integrin, which reside in a cell's outer plasma membrane. Their job is to convert mechanical forces from outside the cell into internal chemical signals that tell the cell what to do. That is, when they work properly. When they misfire, integrins can cause diseases such as atherosclerosis and several types of cancer.

Despite their importance -- good and bad -- scientists don't exactly know how integrins work. That's because it's very difficult to experimentally observe the protein's molecular machinery in action. Scientists have yet to obtain the entire crystal structure of integrin within the plasma membrane, which is a go-to way to study a protein's function. Roadblocks like this have ensured that integrins remain a puzzle despite years of research.

But what if there was another way to study integrin? One that doesn't rely on experimental methods? Now there is, thanks to a computer model of integrin developed by Berkeley Lab researchers. Like its biological counterpart, the virtual integrin snippet is about twenty nanometers long. It also responds to changes in energy and other stimuli just as integrins do in real life. The result is a new way to explore how the protein connects a cell's inner and outer environments.

"We can now run computer simulations that reveal how integrins in the plasma membrane translate external mechanical cues to chemical signals within the cell," says Mohammad Mofrad, a faculty scientist in Berkeley Lab's Physical Biosciences Division and associate professor of Bioengineering and Mechanical Engineering at UC Berkeley. He conducted the research with his graduate student Mehrdad Mehrbod.

They report their research in a recent issue of PLoS Computational Biology.

Their "molecular dynamics" model is the latest example of computational biology, in which scientists use computers to analyze biological phenomena for insights that may not be available via experiment. As you'd expect from a model that accounts for the activities of half a million atoms at once, the integrin model takes a lot of computing horsepower to pull off. Some of its simulations require 48 hours of run time on 600 parallel processors at the U.S. Department of Energy's (DOE) National Energy Research Scientific Computing Center (NERSC), which is located at Berkeley Lab.

The model is already shedding light on what makes integrin tick, such as how they "know" to respond to more force with greater numbers. When activated by an external force, integrins cluster together on a cell's surface and join other proteins to form structures called focal adhesions. These adhesions recruit more integrins when they're subjected to higher forces. As the model indicates, this ability to pull in more integrins on demand may be due to the fact that a subunit of integrin is connected to actin filaments, which form a cell's skeleton.

"We found that if actin filaments sustain more forces, they automatically bring more integrins together, forming a larger cluster," says Mehrbod.

The model may also help answer a longstanding question: Do integrins interact with each other immediately after they're activated? Or do they not interact with each other at all, even as they cluster together?

To find out, the scientists ran simulations that explored whether it's physically possible for integrins to interact when they're embedded in the plasma membrane. They found that interactions are likely to occur only between one compartment of integrin called the ?-subunit.

They also discovered an interesting pattern in which integrins fluctuate. Two integrin sections, one that spans the cell membrane and one that protrudes from the cell, are connected by a hinge-like region. This hinge swings about when the protein is forced to vibrate as a result of frequent kicks from other molecules around it, such as water molecules, lipids, and ions.

These computationally obtained insights could guide new experiments designed to uncover how integrins do their job.

"Our research sets up an avenue for future studies by offering a hypothesis that relates integrin activation and clustering," says Mofrad.

The research was supported by a National Science Foundation CAREER award to Mofrad. NERSC is supported by DOE's Office of Science.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by DOE/Lawrence Berkeley National Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Mehrdad Mehrbod, Mohammad R. K. Mofrad. Localized Lipid Packing of Transmembrane Domains Impedes Integrin Clustering. PLoS Computational Biology, 2013; 9 (3): e1002948 DOI: 10.1371/journal.pcbi.1002948

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Byi8DuN9pCA/130322174339.htm

Jcpenny ohio state football cyber monday lupus iCarly banana republic gap

2nd airport panel removed after fatality in Ala.

BIRMINGHAM, Ala. (AP) ? Airport officials looking into why a flight information panel fell on a family and killed a 10-year-old boy took down an identical sign on Saturday.

Officials at the Birmingham-Shuttlesworth International Airport removed the panel a day after a sign fell on Luke Bresette, of Overland Park, Kan., killing him.

His mother was severely injured and two of his siblings were also hospitalized. The children were being treated at Children's of Alabama. Their mother, Heather Bresette, was taken to University Hospital, where spokeswoman Nicole Wyatt said she is in critical condition.

Firefighters estimated the panel, which displayed arrival and departure times, weighed 300 to 400 pounds. It was located in a recently renovated terminal that includes two concourses.

The airport completed the first phase of a more than $201 million modernization effort and opened newly renovated concourses about a week ago.

Mayor William Bell said he talked with the boy's father ? who was not injured ? and is pressing officials to explain how the sign toppled over.

"I cannot come close to understanding his heartache. But I will get answers. I'm calling on the airport authority to thoroughly investigate this horrible incident. I want a full report on my desk as quickly as possible," he told AL.com.

Airport officials met Saturday, but would not elaborate on other safety measures being taken.

"President and CEO Al Denson and the staff are continuing to work with officials to investigate. This includes discussions with contractors and subcontractors responsible for the modernization," Chairwoman of the Airport Authority Board of Directors Gaynell Hendricks said in a statement. The contractors and subcontractors were not identified.

Airport spokeswoman Toni Herrera-Bast said officials aren't sure how the sign fell. The airport continued operating while rescue workers tended to the family.

Source: http://news.yahoo.com/2nd-airport-panel-removed-fatality-ala-234915788.html

HMS Bounty dominion power Heather Clem Con Edison LaGuardia Airport weather radar the weather channel

Georgia police arrest two teens in baby killing

ATLANTA (Reuters) - Two teenagers were arrested on Friday in the fatal shooting of a 13-month-old boy as his mother was pushing his stroller down the street in a coastal Georgia town, police said.

The child's mother said the baby was shot with a handgun while she was walking along a Brunswick street on Thursday morning, according to Todd Rhodes, Brunswick police spokesman.

Police arrested two boys, ages 17 and 14, on first-degree murder charges, said Rhodes. He would not comment on which of the two suspects was the shooter.

"That's what we're trying to determine," he said.

Officers went door to door in area neighborhoods on Friday looking for the suspects, he said.

The baby's mother was shot in the leg in the attack and was treated and released from a local hospital, Rhodes said.

In an interview with Jacksonville television station WAWS, the mother, identified as Sherry West, said that just before the shooting, the older boy told her: "I'm going to kill you, if you don't give me money."

West responded that she didn't have any money, and then "I put my arms over my baby, and he shoves me and then he shot my baby right in the head."

Earlier on Friday, Rhodes said police were still trying to establish a motive for the shooting.

(Reporting by David Beasley; Editing by Colleen Jenkins, Bernadette Baum, L Gevirtz and Gunna Dickson)

Source: http://news.yahoo.com/u-police-search-young-suspects-georgia-baby-shot-141502117.html

kansas ohio state wrestlemania results womens final four josh hutcherson google april fools office space shell houston open

Adults worldwide eat almost double daily recommended amount of sodium

Mar. 21, 2013 ? Seventy-five percent of the world's population consumes nearly twice the daily recommended amount of sodium (salt), according to research presented at the American Heart Association's Nutrition, Physical Activity and Metabolism and Cardiovascular Disease Epidemiology and Prevention 2013 Scientific Sessions.

Global sodium intake from commercially prepared food, table salt, salt and soy sauce added during cooking averaged nearly 4,000 mg a day in 2010.

The World Health Organization recommends limiting sodium to less than 2,000 mg a day and the American Heart Association recommends limiting sodium to less than 1,500 mg a day.

"This study is the first time that information about sodium intake by country, age and gender is available," said Saman Fahimi, M.D., M.Phil., lead author and a visiting scientist in the Harvard School of Public Health's epidemiology department in Boston, Mass. "We hope our findings will influence national governments to develop public health interventions to lower sodium."

Cardiovascular disease is the number one cause of death in the world; excess sodium intake raises blood pressure. High blood pressure is one of the major contributors to the development of cardiovascular disease.

Among women and men, average sodium intake exceeded healthy levels in almost all countries, researchers said. Kazakhstan had the highest average intake at 6,000 mg per day, followed by Mauritius and Uzbekistan at just less than 6,000 mg per day.

Kenya and Malawi had the lowest average intake at about 2,000 mg per day. In the US, the average intake was about 3,600 mg a day.

One hundred eighty-one of 187 countries, representing 99 percent of the world's population, exceeded the World Health Organization's recommended sodium intake of less than 2,000 mg a day; and 119 countries, representing 88 percent of the world's population, exceeded this recommended intake by more than 1,000 mg a day. All countries except Kenya exceeded the American Heart Association recommended sodium intake of less than 1,500 mg a day.

The researchers analyzed 247 surveys of adult sodium intake to estimate sodium intake, stratified by age, gender, region and nation between 1990 and 2010 as part of the 2010 Global Burden of Diseases Study, which is an international collaborative study by 488 scientists from 303 institutions in 50 countries around the world. .

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by American Heart Association.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/heart_disease/~3/wycB2q81fmM/130321110920.htm

pink slime eagle cam trayvon martin case affordable care act the line us soccer bobby brown arrested